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Kuncoro, Hadi
- Antidiabetic Activity of leaf extract from three types of Mangrove Originating from Sambera Coastal Region Indonesia
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Authors
Affiliations
1 Universitas Mulawarman, Samarinda, ID
2 Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Makassar, ID
3 Laboratorium Pengembangan dan Penelitian Kefarmasian Farmaka Tropis, Fakultas Farmasi, Universitas Mulawarman, Samarinda, ID
1 Universitas Mulawarman, Samarinda, ID
2 Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Makassar, ID
3 Laboratorium Pengembangan dan Penelitian Kefarmasian Farmaka Tropis, Fakultas Farmasi, Universitas Mulawarman, Samarinda, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1707-1712Abstract
This study designed to determine the antidiabetic profile ethanol extracts of leaf extract from three types of mangroves; Avicennia sp., Rhizopora sp, and Sonneratia sp. Extraction process used maceration with ethanol solvent. The phytochemical assayis carried out qualitatively including assay of alkaloids, flavonoids, steroids, terpenoids, phenolic compounds, tannins, and saponins. The method used for the antidiabetic test is the method of blood glucose tolerance. The results showed that ethanol extract of three types of mangrove leaves Avicennia sp., Rhizopora sp, and Sonneratia sp. containing secondary metabolite group alkaloids, flavonoids, steroids, terpenoids, phenolic compounds, tannins, and saponins. Ethanol extract of leaves of the three types of mangroves plants has antidiabetic activity. The ethanol extract of leaves of mangrove Rhizophora sp. with a dose of 200 mg/kg BB + glucose 2 g / kg (group P-2) showed the most excellent antidiabetic activity and lowering blood glucose levels by 31.27%. This study confirmed that three types of Mangrove from Sambera Coastal Region Indonesia showed the antidiabetic profile.Keywords
Avicennia sp., Rhizopora sp, Sonneratia sp., Glucosetolerance, antidiabetic.
References
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- Effect of Ethanol Extract from Purple Eggplant Skin (Solanum melongena L) On Blood Glucose Levels and Pancreatic Β Cells Regeneration on White Rats Male Hypercholesterolemia-Diabetic
Abstract Views :160 |
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Authors
Affiliations
1 Program Studi S1 Farmasi, STIFA Pelita Mas, Palu, ID
2 Laboratorium Penelitian dan Pengembangan Kefarmasian FARMAKA TROPIS, Universitas Mulawarman, Samarinda, ID
1 Program Studi S1 Farmasi, STIFA Pelita Mas, Palu, ID
2 Laboratorium Penelitian dan Pengembangan Kefarmasian FARMAKA TROPIS, Universitas Mulawarman, Samarinda, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2936-2942Abstract
To observed secondary metabolite compounds in the purpleeggplant skin fruit ethanol extract, the effect and effective dose on blood glucose levels and regeneration of pancreatic β cells of white rats male Hypercholesterolemia-Diabetic. This research is a laboratory experiment with a Phytochemical assay using a specified reagent for the ethanol extract of purple eggplant skin. The effect and effective dose on blood glucose levels and regeneration of pancreatic β cells animal model using posttest randomized controlled-group design. A total of 30 rats were divided into six groups. Group I; normal control given standard feed: group II; negative control is given Na CMC 0.5%, high cholesterol feed and induced by streptozotocin 30 mg/kg BW; experimental groups were given extract of ethanol from purple eggplant skin each with dose 25, 50 and 100 mg/kg BW, high cholesterol feed, and streptozotocin 30 mg/kg BW. The data obtained were analyzed using one-way ANOVA test at 95% confidence level and continued with LSD Post Hoc test and description of histologic damage level of the pancreaswas analyzed by Kruskal-Wallis test followed by Mann-Whitney test for observed the difference between treatments. Extracts ethanol of purple eggplant skinaffect blood glucose levels and pancreatic β cell regeneration and an effective dose is a dose of 25 mg/kg body weight was the most effective extract.This research confirm that the ethanol extract from purple eggplant skin (Solanum melongena L) affect blood glucose levels and pancreatic β cell regeneration.Keywords
Solanum Melongena L, Purple Eggplant, Diabetic, Histology, Pancreatic.References
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